Table 4.
Risk factors for recurrence after surgery for pCCA on univariate analysis.
| Parameters | Median Survival | 5 Years RFS | p-Value |
|---|---|---|---|
| Age | |||
| ≤65 | 52 (17.9–86.1) | 38 | 0.03 |
| >65 | 29 (10.1–47.9) | 19 | |
| Bismuth Classification | |||
| I/II | 60 (5.7–114.2) | 43 | 0.539 |
| III/IV | 36 (26.7–45.2) | 30 | |
| Gender | 0.280 | ||
| female | 37 (22.6–51.3) | 30 | |
| male | 28 (12.2–43.7) | 28 | |
| Residual tumor | |||
| R0 | 42 (16–76) | 41 | <0.01 |
| R1 | 26 (0–57.8) | 19 | |
| Tumor differentiation | |||
| Well (G1) | 50 (18.7–81.2) | 45 | <0.01 |
| Moderately/Poor (G2/G3) | 18 (1.9–34.4) | 12 | |
| Lymph node status | |||
| Negative | 40 (24.6–55.4) | 46 | 0.015 |
| Positive | 17 (0.1–36.7) | 17 | |
| Vascular invasion | |||
| No | 40 (10.2–69.7) | 40 | 0.037 |
| Yes | 27 (10.1–43.9) | 15 | |
| Perineural invasion | |||
| No | 45 (11.2–92.3) | 68 | 0.021 |
| Yes | 28 (18.5–55.4) | 30 | |
| Invasion of small lymphatic vessels | |||
| No | 45 (26.3–67.9) | 54 | <0.01 |
| Yes | 28 (18.3–37.6) | 25 | |
| Adjuvant chemotherapy | |||
| No | 30 (21.7–38.2) | 27 | 0.810 |
| Yes | 40 (14.2–65.7) | 29 | |
| Preoperative drainage | |||
| No | 40 (25.8–54.1) | 36 | 0.478 |
| PTCD | 10 (1.6–18.4) | 19 | |
| ERCP | 36 (13.5–58.4) | 25 | |
| AJCC-stage-8th edition | 0.03 | ||
| 1 | 60 (22.4–91.9) | 60 | |
| 2 | 50 (27.1–72.9) | 38 | |
| 3 | 36 (10.6–61.3) | 21 | |
| 4 | 12 (0–38.1) | 0 | |
| Tumor diameter | 0.919 | ||
| <30 | 37 (29.2–44.7) | 36 | |
| >30 | 36 (22.4–49.5) | 31 | |
| Perioperative blood transfusion | |||
| Yes | 17 (0–40.9) | 18 | 0.023 |
| No | 40 (20.3–59.6) | 38 |