Figure 6.

Kaplan–Meier analysis of Overall Survival (a,b) and Leukemia-free Survival (c,d) in the settings of DIPSS categories according to LINC01268 plasma levels. Patients were dichotomized in two subgroups according to DIPSS classification: lowest categories (a,c) correspond to Low and Intermediate-1 classes while highest categories (b,d) include Intermediate-2 and High groups. Patients’ cohort was then stratified according to low and high plasma levels of LINC01268, as previously described in the text. Differences between survival curves were evaluated by Log-rank (Mantel–Cox) test. Blue and red curves represent patients with low or high levels of circulating LINC01268, respectively. HR = hazard ratio computed to determine the magnitude of differences between two curves. † = No event occurred in the Low LINC01268 subgroup; p-value was computed by log-rank test; 95% CI = 95% confidence interval.