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. 2021 Sep 24;13(19):4769. doi: 10.3390/cancers13194769

Figure 9.

Figure 9

Comparison of the tumor growth curves, body weight loss and Kaplan-Meier survival curves for the therapeutic cohorts. (A) Growth curves for the groups of 4T1-luc tumors in the mammary fat pad of BALB/C mice: saline control (blue, n = 6), KGP265 (3 mg/kg) (black, n = 4), carboplatin (30 mg/kg) (green, n = 8) and carboplatin (30 mg/kg) + KGP265 (3 mg/kg) (orange, n = 6). All groups represented only mice surviving over the whole time course. The bars represent the SEM. (B) Growth curves for the groups of orthotopic MDA-MB-231-luc tumors growing in the mammary fat pad of NOD/SCID mice: saline control (blue, n = 13), KGP265 (5 mg/kg) (black, n = 7), carboplatin (50 mg/kg) (green, n = 22), carboplatin (30 mg/kg) + KGP265 (3 mg/kg) (orange, n = 8) and carboplatin (50 mg/kg) + KGP265 (5 mg/kg) (red, n = 8). All groups showed the surviving mice. The bars represent the SEM. (C) The mean change in the body weights for the cohorts of BALB/C mice bearing orthotopic 4T1-luc tumors in the mammary fat pad. All the agents were administered twice-weekly: saline control (blue), KGP265 (3 mg/kg) (black), carboplatin (30 mg/kg) (green) and carboplatin (30 mg/kg) + KGP265 (3 mg/kg) (orange). (D) The mean change in the body weights for the cohorts of NOD/SCID mice bearing orthotopic MDA-MB-231-luc tumors in the mammary fat pad. All the agents were administered twice-weekly: saline control (blue), KGP265 (5 mg/kg) (black), carboplatin (50 mg/kg) (green), carboplatin (30 mg/kg) + KGP265 (3 mg/kg) (orange) and carboplatin (50 mg/kg) + KGP265 (5 mg/kg) (red). (E) Kaplan-Meier survival curves for the groups of 4T1-luc tumors: saline control (blue), KGP265 (3 mg/kg) (black), carboplatin (30 mg/kg) (green) and carboplatin (30 mg/kg) + KGP265 (3 mg/kg) (orange). (F) Kaplan-Meier survival curves for the groups of MDA-MB-231-luc tumors: saline control (blue), KGP265 (3 mg/kg) (black), carboplatin (30 mg/kg) (green), carboplatin (30 mg/kg) + KGP265 (3 mg/kg) (orange) and carboplatin (50 mg/kg) + KGP265 (5 mg/kg) (red).