Comparison 1. Sclerotherapy (any sclerosing agent) versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Resolution or improvement of telangiectasias	4	613	Std. Mean Difference (IV, Random, 95% CI)	3.08 [2.68, 3.48]
1.2 Adverse events	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.2.1 Hyperpigmentation	3	528	Risk Ratio (M‐H, Random, 95% CI)	11.88 [4.54, 31.09]
1.2.2 Matting	3	528	Risk Ratio (M‐H, Random, 95% CI)	4.06 [1.28, 12.84]
1.3 Pain	1		Std. Mean Difference (IV, Random, 95% CI)	Totals not selected