Source	Search strategy	Hits retrieved
VASCULAR REGISTER IN CRSW	1. telang* AND INREGISTER 2. Spider AND INREGISTER 3. reticular near3 vein* AND INREGISTER 4. #1 OR #2 OR #3	29.8.17 ‐ 63 21.1.19 ‐ 2 16.3.21 ‐ 82
CENTRAL via CRSW	#1 MESH DESCRIPTOR Telangiectasis EXPLODE ALL TREES 146 #2 telangiectas*:TI,AB,KY 551 #3 microvaric*:TI,AB,KY 1 #4 (reticular near3 vein*):TI,AB,KY 27 #5 (reticular near3 varic* ):TI,AB,KY 1 #6 (reticular near3 venous ):TI,AB,KY 0 #7 (thread near3 vein* ):TI,AB,KY 0 #8 (thread near3 varic* ):TI,AB,KY 1 #9 (thread near3 venous ):TI,AB,KY 0 #10 (spider near3 vein* ):TI,AB,KY 10 #11 (spider near3 varic* ):TI,AB,KY 1 #12 (spider near3 venous ):TI,AB,KY 1 #13 angioectasias:TI,AB,KY 6 #14 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 574 #15 01/01/2017 TO 22/01/2019:CD 324775 #16 #14 AND #15 177	29.8.17 ‐ 547 21.1.19 ‐ 117 16.3.21 ‐ 228
Clinicaltrials.gov	Telangiectasis OR telangiectatic OR "reticular veins" OR "reticular vein" OR "spider veins" OR "spider vein" OR "thread veins" OR "thread vein" OR angioectasias | Interventional Studies	29.8.17 ‐ 136 21.1.19 ‐ 18 16.3.21 ‐ 30
ICTRP Search Portal	Telangiecta* OR reticular vein* OR spider vein* OR thread vein* OR angioectasias	29.8.17 ‐ 131 21.1.19 ‐ 31 16.3.21 ‐ 43
Ovid MEDLINE Epub Ahead of Print, In‐Process & Other Non‐Indexed Citations, Ovid MEDLINE Daily and Ovid MEDLINE 1946 to Present	1 exp Telangiectasis/ 2 telangiectas*.ti,ab. 3 microvaric*.ti,ab. 4 (reticular adj3 varic*).ti,ab. 5 (reticular adj3 vein*).ti,ab. 6 (reticular adj3 venous).ti,ab. 7 (thread adj3 vein*).ti,ab. 8 (thread adj3 varic*).ti,ab. 9 (thread adj3 venous).ti,ab. 10 (spider adj3 vein*).ti,ab. 11 (spider adj3 varic*).ti,ab. 12 (spider adj3 venous).ti,ab. 13 angioectasias.ti,ab. 14 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 15 limit 14 to yr="2017" 16 randomized controlled trial.pt. 17 controlled clinical trial.pt. 18 randomized.ab. 19 placebo.ab. 20 drug therapy.fs. 21 randomly.ab. 22 trial.ab. 23 groups.ab. 24 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 25 exp animals/ not humans.sh. 26 24 not 25 27 15 and 26	29.8.17 ‐ 45 21.1.19 ‐ 235 16.3.21 ‐ 230
Embase Ovid	1 exp Telangiectasis/ 2 telangiectas*.ti,ab. 3 microvaric*.ti,ab. 4 (reticular adj3 varic*).ti,ab. 5 (reticular adj3 vein*).ti,ab. 6 (reticular adj3 venous).ti,ab. 7 (thread adj3 vein*).ti,ab. 8 (thread adj3 varic*).ti,ab. 9 (thread adj3 venous).ti,ab. 10 (spider adj3 vein*).ti,ab. 11 (spider adj3 varic*).ti,ab. 12 (spider adj3 venous).ti,ab. 13 angioectasias.ti,ab. 14 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 15 limit 14 to yr="2017" 16 randomized controlled trial/ 17 controlled clinical trial/ 18 random$.ti,ab. 19 randomization/ 20 intermethod comparison/ 21 placebo.ti,ab. 22 (compare or compared or comparison).ti. 23 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab. 24 (open adj label).ti,ab. 25 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab. 26 double blind procedure/ 27 parallel group$1.ti,ab. 28 (crossover or cross over).ti,ab. 29 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab. 30 (assigned or allocated).ti,ab. 31 (controlled adj7 (study or design or trial)).ti,ab. 32 (volunteer or volunteers).ti,ab. 33 trial.ti. 34 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 35 15 and 34	29.8.17 ‐ 99 21.1.19 ‐ 581 16.3.21 ‐ 487
AMED (Allied and Complementary Medicine)	1. telangiectas*.ti,ab. 2. microvaric*.ti,ab. 3. (reticular adj3 varic*).ti,ab. 4. (reticular adj3 vein*).ti,ab. 5. (reticular adj3 venous).ti,ab. 6. (thread adj3 vein*).ti,ab. 7. (thread adj3 varic*).ti,ab. 8. (thread adj3 venous).ti,ab. 9. (spider adj3 vein*).ti,ab. 10. (spider adj3 varic*).ti,ab. 11. (spider adj3 venous).ti,ab. 12. angioectasias.ti,ab. 13. or/1‐12 14. exp CLINICAL TRIALS/ 15. RANDOM ALLOCATION/ 16. DOUBLE BLIND METHOD/ 17. Clinical trial.pt. 18. (clinic* adj trial*).tw. 19. ((singl* or doubl* or trebl* or tripl*) adj (blind* or mask*)).tw. 20. PLACEBOS/ 21. placebo*.tw. 22. random*.tw. 23. PROSPECTIVE STUDIES/ 24. or/14‐23 25. 13 and 2	29.8.17 ‐ 0 21.1.19 ‐ 0 16.3.21 ‐ 0
CINAHL	S30 S28 AND S29 S29 EM 2017 OR EM 2018 OR 2019 EM S28 S14 AND S27 S27 S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 S26 MH "Random Assignment" S25 MH "Single‐Blind Studies" or MH "Double‐Blind Studies" or MH "Triple‐Blind Studies" S24 MH "Crossover Design" S23 MH "Factorial Design" S22 MH "Placebos" S21 MH "Clinical Trials" S20 TX "multi‐centre study" OR "multi‐center study" OR "multicentre study" OR "multicenter study" OR "multi‐site study" S19 TX crossover OR "cross‐over" S18 AB placebo* S17 TX random* S16 TX trial* S15 TX "latin square" S14 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 S13 TX angioectasias S12 TX spider venous S11 TX spider varic* S10 TX spider vein* S9 TX thread venous S8 TX thread varic* S7 TX thread vein* S6 TX reticular venous S5 TX reticular varic* S4 TX reticular vein* S3 TX telangiectas* S2 (MH "Telangiectasis+") S1 TX Telangiectasis	29.8.17 ‐ 49 21.1.19 ‐ 41 16.3.21 ‐ 23