Nguyen 2020.
| Study characteristics | ||
| Methods |
Study design: randomised controlled trial Method of randomisation: randomisation by right or left limb Blinding: participants ‐ no, doctor ‐ no, outcome assessors ‐ yes Power calculation: not mentioned Total number of participants: 22 Total number of procedures: 44 Treatment localisation: lower extremity Number of exclusions post‐randomisation: none Number of withdrawals and reasons: none |
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| Participants |
Setting: outpatient site Country: Vietnam Gender: both genders Age: mean 32 years Inclusion criteria: skin photo type IV and lower extremity telangiectases or reticular veins (CEAP C1) Exclusion criteria: pregnancy; lactation; anticoagulation agent use; active skin infection; or history of herpes simplex infection, thrombosis, hypercoagulability, diabetes, hypertrophic/keloid scar, and cardiovascular, renal, and liver disease |
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| Interventions | The Laser 1064 was used in right leg, a single pass with 5 mm fixed spot size, pulse width of 20 ms for telangiectasias, and 30 ms for reticular veins and fluences of 120 to 220J/cm2 was used The Laser 755 was used in left side, a single pass with 5 mm fixed spot size, pulse width of 12 ms for telangiectasia, and 20 ms for reticular veins and fluences of 55 to 140J/cm2 was used In all cases, fluence levels were adjusted to achieve clinical endpoints of vessel blanching or greyish colour within the vessel |
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| Outcomes | Pain level Efficacy was evaluated by clinical examination and comparison of pre‐ and post‐treatment standardised photos |
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| Funding sources | No funding received | |
| Declarations of interest | None declared | |
| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | High risk | Quasi‐randomised, randomisation by right or left limb |
| Allocation concealment (selection bias) | Unclear risk | No details given |
| Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | No details given |
| Blinding of outcome assessment (detection bias) All outcomes | Low risk | All results were independently evaluated by 2 authors |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | No details given |
| Selective reporting (reporting bias) | Unclear risk | No details given |
| Other bias | Unclear risk | No details given |