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. 2021 Oct 6;13(19):5009. doi: 10.3390/cancers13195009

Figure 2.

Figure 2

Surprisal analysis predicts efficient drug combinations for TNBC cell lines. (A,B) Barcode (A) representing the set of unbalanced processes in MDA-MB-468 cells, according to PaSSS analysis (B); (C,D) Barcode (C) representing the set of unbalanced processes in MDA-MB-231 cells, according to PaSSS analysis (D). Central protein targets from each process and the corresponding drugs (connected by inhibition arrows) are shown in B and D. (Abbreviations: TNBC—Triple Negative Breast Cancer, pEGFR—phospho Epidermal Growth Factor Receptor, PaSSS—Patient-specific signaling signature, ER—Estrogen receptor, GAPDH—Glyceraldehyde 3-phosphate dehydrogenase, pMEK—phospho Mitogen-activated protein kinase kinase, pERK—phospho Extracellular signal-regulated kinase).