Table 2.
Mutations detected in vimentin in different human cancers. Data extracted from The Cancer Genome Atlas database (TCGA) [159].
| Cancer Type/Study of Origin | Mutation | Mutation Type | Effect of Mutation on Copy Number | TCGA Sample ID |
|---|---|---|---|---|
| Oligodendroglioma | NPM1-VIM | GENE FUSION | Shallow Deletion | TCGA-FG-6692-01 |
| Dedifferentiated Sarcoma | COL3A1-VIM | GENE FUSION | Diploid | TCGA-DX-A48N-01 |
| Dedifferentiated Sarcoma | COL1A1-VIM | GENE FUSION | Diploid | TCGA-DX-A7EI-01 |
| Myxofibrosarcoma | TNXB-VIM | GENE FUSION | Gain | TCGA-DX-AB2T-01 |
| Cutaneous Melanoma | S100A6-VIM | GENE FUSION | Not known | TCGA-GN-A26C-01 |
| Cutaneous Melanoma | HSPG2-VIM | GENE FUSION | Not known | TCGA-GN-A26C-01 |
| Cutaneous Melanoma | E156K | Missense_Mutation | Not known | TCGA-BF-A5EQ-01 |
| Cutaneous Melanoma | E156K | Missense_Mutation | Gain | TCGA-D3-A3MR-06 |
| Cervical Squamous Cell Carcinoma | E153D | Missense_Mutation | Diploid | TCGA-IR-A3LK-01 |
| Adrenocortical Carcinoma | A247P | Missense_Mutation | Gain | TCGA-OR-A5KB-01 |
| Astrocytoma | M372V | Missense_Mutation | Diploid | TCGA-DU-6392-01 |
| Astrocytoma | E407V | Missense_Mutation | Diploid | TCGA-DU-6392-01 |
| Serous Ovarian Cancer | E407K | Missense_Mutation | Gain | TCGA-59-2348-01 |
| Serous Ovarian Cancer | R320Q | Missense_Mutation | Not known | TCGA-23-2649-01 |
| Serous Ovarian Cancer | R364L | Missense_Mutation | ShallowDel | TCGA-24-1849-01 |
| Serous Ovarian Cancer | N283D | Missense_Mutation | Diploid | TCGA-25-2397-01 |
| Glioblastoma Multiforme | A301T | Missense_Mutation | Diploid | TCGA-06-5416-01 |
| Glioblastoma Multiforme | E95Q | Missense_Mutation | Shallow Deletion | TCGA-14-0866-01 |
| Sarcoma ** | V171F | Missense_Mutation | Diploid | TCGA-X9-A973-01 |
| Lung Squamous Cell Carcinoma | F15L | Missense_Mutation | Diploid | TCGA-21-5782-01 |
| Lung Squamous Cell Carcinoma | R222L | Missense_Mutation | Diploid | TCGA-33-4587-01 |
| Lung Squamous Cell Carcinoma | E244K | Missense_Mutation | Diploid | TCGA-37-3783-01 |
| Lung Squamous Cell Carcinoma | A332S | Missense_Mutation | Shallow Deletion | TCGA-39-5021-01 |
| Lung Squamous Cell Carcinoma | E187G | Missense_Mutation | Shallow Deletion | TCGA-39-5036-01 |
| Lung Squamous Cell Carcinoma | L340M | Missense_Mutation | Shallow Deletion | TCGA-22-4613-01 |
| Lung Squamous Cell Carcinoma | D429Y | Missense_Mutation | Diploid | TCGA-39-5035-01 |
| Bladder Urothelial Carcinoma | E407K | Missense_Mutation | Gain | TCGA-KQ-A41P-01 |
| Bladder Urothelial Carcinoma | R217H | Missense_Mutation | Diploid | TCGA-2F-A9KQ-01 |
| Bladder Urothelial Carcinoma | S278R | Missense_Mutation | Gain | TCGA-4Z-AA80-01 |
| Bladder Urothelial Carcinoma | E396Q | Missense_Mutation | Diploid | TCGA-DK-A1AB-01 |
| Bladder Urothelial Carcinoma | R50H | Missense_Mutation | Diploid | TCGA-DK-A3WW-01 |
| Bladder Urothelial Carcinoma | S8L | Missense_Mutation | Gain | TCGA-XF-A9SJ-01 |
| Hepatocellular Carcinoma | Q81L | Missense_Mutation | Gain | TCGA-G3-A5SM-01 |
| Hepatocellular Carcinoma | S22I | Missense_Mutation | Diploid | TCGA-DD-AACY-01 |
| Hepatocellular Carcinoma | X209_splice | Splice_acceptor_variant | Gain | TCGA-CC-A8HV-01 |
| Hepatocellular Carcinoma | R424W | Missense_Mutation | Gain | TCGA-ED-A66Y-01 |
| Prostate Adenocarcinoma | T33M | Missense_Mutation | Diploid | TCGA-XK-AAIW-01 |
| Renal Clear Cell Carcinoma | L380F | Missense_Mutation | Diploid | TCGA-CJ-4869-01 |
| Endometrial Carcinoma *** | E221K | Missense_Mutation | Diploid | TCGA-A5-A0G2-01 |
| Uterine Endometrioid Carcinoma | R345H | Missense_Mutation | Diploid | TCGA-AJ-A3EL-01 |
| Uterine Endometrioid Carcinoma | D257N | Missense_Mutation | Diploid | TCGA-AP-A056-01 |
| Uterine Endometrioid Carcinoma | T266M | Missense_Mutation | Diploid | TCGA-AP-A059-01 |
| Uterine Endometrioid Carcinoma | E198Rfs*38 | Frame_Shift_Insertion | Diploid | TCGA-B5-A0JZ-01 |
| Uterine Endometrioid Carcinoma | R217C | Missense_Mutation | Diploid | TCGA-B5-A11E-01 |
| Uterine Endometrioid Carcinoma | E354K | Missense_Mutation | Gain | TCGA-BG-A0LX-01 |
| Uterine Endometrioid Carcinoma | L215V | Missense_Mutation | Diploid | TCGA-BG-A18C-01 |
| Uterine Endometrioid Carcinoma | E457K | Missense_Mutation | Diploid | TCGA-BS-A0TC-01 |
| Uterine Endometrioid Carcinoma | E349D | Missense_Mutation | Diploid | TCGA-EO-A22R-01 |
| Endometrial Carcinoma *** | S438 * | Nonsense_Mutation | Shallow Deletion | TCGA-EY-A1GS-01 |
| Endometrial Carcinoma *** | L380I | Missense_Mutation | Diploid | TCGA-A5-A0G2-01 |
| Uterine Endometrioid Carcinoma | E346 * | Nonsense_Mutation | Diploid | TCGA-A5-A2K5-01 |
| Uterine Endometrioid Carcinoma | R310S | Missense_Mutation | Diploid | TCGA-AJ-A3EK-01 |
| Uterine Endometrioid Carcinoma | R410= | Splice_Region, silent | Diploid | TCGA-AP-A1DV-01 |
| Uterine Endometrioid Carcinoma | L149F | Missense_Mutation | Diploid | TCGA-B5-A3F9-01 |
| Uterine Endometrioid Carcinoma | S325P | Missense_Mutation | Diploid | TCGA-B5-A3FC-01 |
| Uterine Endometrioid Carcinoma | V224L | Missense_Mutation | Diploid | TCGA-EO-A3AY-01 |
| Uterine Endometrioid Carcinoma | L131R | Missense_Mutation | Diploid | TCGA-EY-A1GD-01 |
| Uterine Endometrioid Carcinoma | F15V | Missense_Mutation | Diploid | TCGA-FI-A2D5-01 |
| Uterine Endometrioid Carcinoma | A247V | Missense_Mutation | Diploid | TCGA-FI-A2D5-01 |
| Lung Adenocarcinoma | E239K | Missense_Mutation | Gain | TCGA-05-4432-01 |
| Lung Adenocarcinoma | E225 * | Nonsense_Mutation | Gain | TCGA-44-7671-01 |
| Lung Adenocarcinoma | D259Y | Missense_Mutation | Gain | TCGA-73-A9RS-01 |
| Lung Adenocarcinoma | L234 * | Frame_Shift_Del | Gain | TCGA-86-A4JF-01 |
| Lung Adenocarcinoma | Q314 * | Nonsense_Mutation | Shallow Deletion | TCGA-95-7043-01 |
| Lung Adenocarcinoma | X209_splice | splice_acceptor_variant | Gain | TCGA-55-8301-01 |
| Esophagogastric Adenocarcinoma | K390T | Missense_Mutation | Shallow Deletion | TCGA-L5-A4OT-01 |
| Esophagogastric Adenocarcinoma | E288D | Missense_Mutation | Gain | TCGA-R6-A6DN-01 |
| Cutaneous Melanoma | S325F | Missense_Mutation | ShallowDel | TCGA-EE-A2GC-06 |
| Cutaneous Melanoma | P57R | Missense_Mutation | ShallowDel | TCGA-EE-A3JI-06 |
| Cutaneous Melanoma | P432L | Missense_Mutation | ShallowDel | TCGA-EE-A181-06 |
| Cutaneous Melanoma | E172K | Missense_Mutation | Diploid | TCGA-EB-A5UL-06 |
| Cutaneous Melanoma | L326F | Missense_Mutation | Not known | TCGA-EB-A41B-01 |
| Cutaneous Melanoma | S420F | Missense_Mutation | Diploid | TCGA-WE-A8K5-06 |
| Cutaneous Melanoma | R186L | Missense_Mutation | Diploid | TCGA-D3-A2JB-06 |
| Cutaneous Melanoma | R36S | Missense_Mutation | Diploid | TCGA-D3-A2JH-06 |
| Cutaneous Melanoma | S339F | Missense_Mutation | Diploid | TCGA-D3-A8GL-06 |
| Cutaneous Melanoma | E230K | Missense_Mutation | Gain | TCGA-D3-A8GM-06 |
| Cutaneous Melanoma | A287T | Missense_Mutation | Diploid | TCGA-W3-A824-06 |
| Cutaneous Melanoma | R155Q | Missense_Mutation | Diploid | TCGA-WE-A8K5-06 |
| Diffuse Type Stomach Adenocarcinoma | R345C | Missense_Mutation | Amplification | TCGA-HU-A4GU-01 |
| Mucinous Stomach Adenocarcinoma | R345H | Missense_Mutation | Diploid | TCGA-CD-8529-01 |
| Intestinal Type Stomach Adenocarcinoma | T266M | Missense_Mutation | Diploid | TCGA-VQ-A91K-01 |
| Tubular Stomach Adenocarcinoma | E349D | Missense_Mutation | Diploid | TCGA-BR-8680-01 |
| Stomach Adenocarcinoma | V434A | Missense_Mutation | Diploid | TCGA-BR-4292-01 |
| Intestinal Type Stomach Adenocarcinoma | R270H | Missense_Mutation | Diploid | TCGA-BR-7851-01 |
| Stomach Adenocarcinoma | L421P | Missense_Mutation | Diploid | TCGA-BR-8372-01 |
| Stomach Adenocarcinoma | X337_splice | splice_acceptor_variant | Diploid | TCGA-BR-8487-01 |
| Stomach Adenocarcinoma | Y319C | Missense_Mutation | Diploid | TCGA-BR-A4QM-01 |
| Diffuse Type Stomach Adenocarcinoma | F295S | Missense_Mutation | Diploid | TCGA-CD-A489-01 |
| Tubular Stomach Adenocarcinoma | E407D | Missense_Mutation | Shallow Deletion | TCGA-D7-6528-01 |
| Diffuse Type Stomach Adenocarcinoma | K390T | Missense_Mutation | Diploid | TCGA-D7-A747-01 |
| Breast Invasive Ductal Carcinoma | R450T | Missense_Mutation | Diploid | TCGA-C8-A12T-01 |
| Breast Invasive Ductal Carcinoma | E221K | Missense_Mutation | Diploid | TCGA-AC-A23H-01 |
| Breast Invasive Ductal Carcinoma | Q195H | Missense_Mutation | Diploid | TCGA-A7-A26H-01 |
| Breast Invasive Ductal Carcinoma | V77Cfs*34 | Frame_Shift_Deletion | Diploid | TCGA-D8-A27V-01 |
| Rectal Adenocarcinoma | R345C | Missense_Mutation | Diploid | TCGA-AG-3892-01 |
| Mucinous Adenocarcinoma of the Colon and Rectum | R310C | Missense_Mutation | Diploid | TCGA-CA-6717-01 |
| Mucinous Adenocarcinoma of the Colon and Rectum | R71W | Missense_Mutation | Diploid | TCGA-AD-5900-01 |
| Papillary Renal Cell Carcinoma | A308G | Missense_Mutation | Diploid | TCGA-DW-7842-01 |
| Head and Neck Squamous Cell Carcinoma | P57L | Missense_Mutation | Diploid | TCGA-CN-A640-01 |
| Head and Neck Squamous Cell Carcinoma | R304Q | Missense_Mutation | Amplification | TCGA-UF-A71D-01 |
| Head and Neck Squamous Cell Carcinoma | R304Q | Missense_Mutation | Gain | TCGA-CN-4727-01 |
| Head and Neck Squamous Cell Carcinoma | D211H | Missense_Mutation | Diploid | TCGA-CR-6481-01 |
*: stop codon; **: Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma/High-Grade Spindle Cell Sarcoma; ***: Uterine Serous Carcinoma/Uterine Papillary Serous Carcinoma.