Table 1.
Coregulators of PR transcriptional action [30,84]. Molecular function of the proteins as stated in the UniProt online database https://www.uniprot.org/ [91]. Depending on the molecular context the BRG1 protein can act as a coactivator (for example serving as a component of the SWI/SNF complex) or as a corepressor [84,91].
| Coregulator Type | Gene (Protein) Name | Molecular Function |
|---|---|---|
| Coactivator | NCOA1 (Nuclear Receptor Coactivator 1) also known as SRC1 | Acyltransferase, activator |
| NCOA3 (Nuclear Receptor Coactivator 3) also known as SRC3 | ||
| EP300 (Histone acetyltransferase p300) | ||
| CREBBP (CREB-binding protein) | ||
| NCOA2 (Nuclear Receptor Coactivator 2) also known as SRC2, TIF2 or GRIP1 | Activator | |
| Components of the SWI/SNF (Switch/Sucrose Non-Fermentable) complex | Helicase, DNA-binding, hydrolase, chromatin regulator | |
| UBE3A (Ubiquitin-protein ligase E3A) also known as E6AP | Transferase | |
| CARM1 (Histone-arginine methyltransferase CARM1) | Methyltransferase, chromatin regulator | |
| SRA1 (Steroid receptor RNA activator 1) | Receptor, activator | |
| Corepressor | NCOR1 (Nuclear receptor corepressor 1) | DNA-binding, chromatin regulator, repressor |
| NCOR2 (Nuclear receptor corepressor 1) also known as SMRT | DNA-binding, repressor | |
| HDAC1 (Histone deacetylase 1) | Hydrolase, chromatin regulator, repressor | |
| HDAC2 (Histone deacetylase 2) | ||
| RCOR1 (REST corepressor 1) | Chromatin regulator, repressor | |
| CBX3 (Chromobox protein homolog 3) also known as HP1γ | ||
| KDM1A (Lysine-specific histone demethylase 1A) also known as LSD1 | Oxidoreductase, chromatin regulator, repressor | |
| Coactivator/corepressor | SMARCA4 (Transcription activator BRG1) | Helicase, hydrolase, chromatin regulator, activator, repressor, RNA-binding |