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Both INI1 immunonegativity (p = 0.002) and IDH2 p.Arg172x mutation (p = 0.036) correlate to LINE-1 hypermethylation. LINE-1 methylation level (%) is reported in y-axis as a continuous variable. (a) LINE-1 methylation levels of INI1 negative versus INI1 positive cases. Red dots are representative of two cases showing BRG1 loss of immunoreactivity; (b) LINE-1 methylation levels of IDH2 mutant versus IDH2 wild-type (wt) cases.
