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Multivariate analysis of overall survival 1. A Cox proportional hazards model for overall survival was calculated, including our biomarkers TOP2A and SIRT1 and statistically significant clinical parameters.
| Factor | Strata | Significance | Hazard Ratio | 95.0% CI |
|---|---|---|---|---|
| Surgical margins | R0/R1 vs. R2 or no resection | 0.0001 | 2.735 | (1.632–4.581) |
| Age | 0.020 | 1.018 | (1.003–1.033) | |
| Grade | G2 vs. G3 | 0.136 | 1.409 | (0.897–2.213) |
| TOP2A | Low vs. high | 0.058 | 1.566 | (0.985–2.489) |
| SIRT1 | High vs. low | 0.004 | 1.935 | (1.240–3.018) |
