Table 4.

Multivariate analysis of overall survival 2. A Cox proportional hazards model for overall survival was calculated, including the favorable “Top Survivor” biomarker combination (low TOP2A and high SIRT1) and statistically significant clinical parameters.

Factor	Strata	Significance	Hazard Ratio	95.0% CI
Surgical margins	R0/R1 vs. R2 or no resection	0.0001	2.839	(1.696–4.752)
Age	-	0.022	1.017	(1.003–1.032)
Grade	G2 vs. G3	0.153	1.362	(0.891–2.081)
Biomarker	High SIRT1 and low TOP2A	0.002	2.547	(1.406–4.612)