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To determine reversibility of SSTR2 upregulation upon HDACi withdrawal, SSTR2 mRNA levels were determined by RT-qPCR directly after treatment with HDACi at the IC50 dose (D0), and one (D1), three (D3), and seven days (D7) after HDACi withdrawal for BON-1 (A), and at D0, D1, and D3 for NCI-H727 (B). Results were normalized to vehicle-treated cells. * p < 0.05, ** p < 0.01, *** p < 0.001, NS; non-significant.
