Table 2.
Characteristics and consequences of irAEs.
| Characteristics | All Cases (n = 79) |
Late-Onset AEs (≥2 Years) (n = 4) |
|---|---|---|
| Type of AEs, n (%) | ||
| Cardiology | 3 (4) Atrioventricular block, Myocarditis (2) |
1 (25) Myocarditis |
| Hepatogastroenterology | 37 (47) Immune colitis (15), Diarrhea (2), Cholangitis (7), Hepatitis (13) |
1 (25) Hepatitis |
| General | 5 (6) Asthenia (3), Multiple organ failure, Hypernatremia |
|
| Hematology | 2 (2) Anemia, Hyper eosinophilia |
|
| Immunology | 3 (4) Hypophysis (2), acute GvH |
|
| Musculoskeletal system | 4 (5) Myalgia, Myasthenia, Arthralgia, Elevation of CPK |
|
| Ophthalmology | 1 (1) Optic retrobulbar neuritis |
1 (25) Optic retrobulbar neuritis |
| Dermatology | 12 (15) Pruritus (3), Rash (5), Carcinoma, SJS, Bullous pemphigoid (2) |
1 (25) Pruritus |
| Pneumology | 5 (6) Immune pneumonitis (4), Pulmonary embolism |
|
| Nephrology | 3 (4) Acute renal failure, Tubulointerstitial nephritis (2) |
|
| Neurology | 4 (5) Apraxia, Demyelinating neuropathy, Neuropathy, Unknown |
|
| Grade, n (%) * | ||
| 3 | 70 (88) | 2 (50) |
| 4 | 9 (12) | 2 (50) |
| Sequelae, n (%) * | ||
| Yes (except death) | 12 (19) | 2 (67) |
| Death | 2 (3) | 0 (0) |
| No | 50 (78) | 1 (33) |
* Missing data.