Total				Study 1	Study 2	Study 3	Study 4	Study 5	Study 6	Study 7	Study 8	Study 9	Study 10	Study 11	Study 12	Study 13	Study 14	Study 15	Study 16	Study 17
Criteria	Yes	Partial	No	NA	Celler B et al	Dastoon M et al	De Walt et al	Dinesen B et al	Estaban C et al	Frederix et al	Greenup EP et al	Howie-Esquivel J et al	Krumholz HM et al	Ong MK	Pinnock H et al	Rosen OZ et al	Rosnar BI et al	Sorknaes ED et al	Takahashi PY et al	Wang Y et al	White M et al
Objective sufficiently described	14	3	0	0	2	2	1	1	1	2	2	2	2	2	2	2	2	2	2	2	2
Study design evident and appropriate	15	2	0	0	2	2	2	2	1	2	1	2	2	2	2	2	2	2	2	2	2
Source of information appropriate	15	2	0	0	2	2	2	2	2	1	1	2	2	2	2	2	2	2	2	2	2
Baseline characteristics described	12	5	0	0	2	2	2	2	2	1	1	2	2	2	2	2	2	1	1	1	2
Random allocation	8		1	8	NA	2	2	2	NA	2	NA	NA	2	2	2	NA	NA	0	2	2	NA
Blinding of investigators	3	3	12	0	NA	2	2	2	NA	2	NA	NA	2	2	2	NA	NA	0	2	1	NA
Blinding of subjects	2	2	5	8	NA	1	1	2	NA	2	NA	NA	0	0	0	NA	NA	0	0	2	NA
Outcome well defined	17	0	0	0	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
Sample size appropriate	7	10	0	0	1	1	2	1	2	1	1	1	1	2	2	2	2	1	1	1	2
Analytic methods appropriate	15	2	0	0	2	2	2	1	2	1	2	2	2	2	2	2	2	2	2	2	2
Variance is reported	9	1	7	0	2	2	2	2	2	0	2	2	2	2	1	0	0	0	0	0	0
Controlled for confounding	4	5	8	0	2	0	1	0	0	0	1	1	2	2	1	2	1	0	0	0	0
Results reported appropriate	14	3	0	0	2	2	1	1	2	1	2	2	2	2	2	2	2	2	2	2	2
Conclusions appropriate	12	5			2	1	1	2	1	1	2	2	2	2	1	2	2	2	2	2	2
Summary Score	-	-	-	-	95	82	82	79	77	64	77	91	89	93	82	91	86	57	71	75	82
Total score/Numerator	147	43	33	16	21	23	23	22	17	18	17	20	25	26	23	20	19	16	20	21	18
Denominator	28	14			22	28	28	28	22	28	22	22	28	28	28	22	22	28	28	28	22