Table 3.
Results of Cox regression univariate analysis for 5 lncRNAs with an unfavorable clinical outcome by Kaplan–Meier analysis. Higher expression level based on median cutoff in 497 MM dataset was tested in both OS and PFS. Significant p-values are marked in bold. Number (N) and fraction of MM patients at higher expression levels are indicated for each lncRNA. Clinical and molecular variables important for MM were also tested.
| OS Univariate Cox Analysis | PFS Univariate Cox Analysis | ||||
|---|---|---|---|---|---|
| Molecular Lesion | N (%) High Level | HR (95% CI) | p-Value | HR (95% CI) | p-Value |
| Linc00886.median | 240 (48%) | 0.65 (0.45–0.94) | 0.0213 | 0.73 (0.57–0.95) | 0.017 |
| NINJ2-AS1.median | 246 (49%) | 0.71 (0.49–1.03) | 0.0691 | 0.76 (0.59–0.99) | 0.0386 |
| AL513412.1.median | 233 (47%) | 0.77 (0.53–1.12) | 0.173 | 0.78 (0.60–1.01) | 0.0641 |
| Linc02728.median | 263 (53%) | 0.79 (0.55–1.13) | 0.195 | 0.76 (0.59–0.98) | 0.0343 |
| SNHG6.median | 262 (53%) | 1.45 (1.00–2.09) | 0.0478 | 1.11 (0.86–1.43) | 0.437 |
| del1p.CDKN2C | 143 (29%) | 1.61 (1.10–2.35) | 0.0148 | 1.30 (0.98–1.71) | 0.0646 |
| del13q.RB1 | 258 (52%) | 2.11 (1.44–3.09) | 0.000119 | 1.71 (1.32–2.21) | 4.71 × 10−5 |
| HD | 281 (57%) | 0.64 (0.44–0.92) | 0.0149 | 0.67 (0.52–0.86) | 0.00166 |
| TP53.alt.1q.gain.amp | 19 (4%) | 3.63 (1.89–6.97) | 0.000103 | 2.46 (1.38–4.42) | 0.00243 |
| TP53.alt | 40 (8%) | 1.05 (0.53–2.07) | 0.892 | 0.85 (0.52–1.39) | 0.511 |
| gain.amp.1q | 164 (33%) | 1.68 (1.17–2.43) | 0.0051 | 1.52 (1.17–1.98) | 0.00151 |
| DIS3mut | 50 (10%) | 1.63 (1.06–2.50) | 0.0264 | 1.62 (1.18–2.22) | 0.00308 |
| NRASmut | 117 (24%) | 0.90 (0.62–1.32) | 0.596 | 1.01 (0.79–1.29) | 0.924 |
| KRASmut | 121 (24%) | 1.07 (0.77–1.49) | 0.694 | 1.03 (0.80–1.31) | 0.827 |
| BRAF.mut | 36 (7%) | 1.18 (0.60–2.31) | 0.628 | 0.88 (0.52–1.48) | 0.626 |
| FAM46C.mut | 49 (10%) | 0.78 (0.42–1.43) | 0.419 | 1.07 (0.74–1.53) | 0.728 |
| TRAF3.mut | 38 (8%) | 0.42 (0.17–1.06) | 0.0668 | 0.80 (0.52–1.22) | 0.297 |
| t11.14 | 102 (21%) | 0.92 (0.58–1.46) | 0.726 | 0.94 (0.68–1.30) | 0.694 |
| t4.14 | 69 (14%) | 1.63 (1.04–2.55) | 0.0335 | 1.60 (1.14–2.23) | 0.00612 |
| trx.MAF | 33 (7%) | 1.96 (1.08–3.57) | 0.0276 | 1.63 (1.03–2.57) | 0.0376 |
| trx.MYC | 20 (4%) | 1.92 (0.94–3.94) | 0.0748 | 1.94 (1.13–3.34) | 0.0163 |
| ISS I | 187 (38%) | 0.31 (0.19–0.50) | 1.86 × 10−6 | 0.46 (0.34–0.61) | 1.20 × 10−7 |
| ISS II | 171 (34%) | 1.13 (0.78–1.64) | 0.524 | 1.18 (0.91–1.54) | 0.213 |
| ISS III | 139 (28%) | 2.45 (1.70–3.53) | 1.62 × 10−6 | 1.92 (1.48–2.50) | 1.14 × 10−6 |