Figure 2.

lncRNA-protein interactions in melanoma cells. The mechanism of action and function of various lncRNAs is predominantly imposed by their subcellular localization. lncRNAs can reside in the nucleus, where they bind to activators or repressors of transcription, as well as to transcription factors, thereby regulating the expression of target genes. Cytosolic lncRNAs modulate signaling pathways that control melanoma cell proliferation, invasion and migration. Mitochondrial lncRNAs control oxidative phosphorylation and sensitivity to apoptosis. Dashed arrow indicates indirect activation of expression.