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The mechanism of sponging activity of lncRNAs and circRNAs. (A) In the absence of lncRNAs, abundant miRNAs bind to the 3′ untranslated region of target transcripts and block their translation. (B,C). lncRNAs or circRNAs, when present, outcompete target transcripts in miRNA binding, which results in the rescue of translation blockade of target transcripts.
