Table 2.
lncRNA and circRNAs with miRNA sponging activity in melanoma.
| lncRNA | Function | Expression in Melanoma a | miRNA-mRNA Axis | References |
|---|---|---|---|---|
| BANCR | oncogene | upregulated | miR-204-5p/notch2 | [107] |
| CASC2 | tumor suppressor | downregulated | miR-18a-5p/RUNX1 miR-181a/PLXNC1 |
[108] [109] |
| CCAT1 | oncogene | upregulated | miR-33a/N/A miR-296-3p/ITGA9 |
[110] [111] |
| circ_0002770 | oncogene | upregulated | miR-331-3p/DUSP5, TGFBR1 | [112] |
| circ_0016418 | oncogene | upregulated | miR-625/YY1 | [113] |
| circ_0020710 | oncogene | upregulated | miR-370-3p/CXCL12 | [114] |
| circ_0025039 | oncogene | upregulated | miR-198/CDK4 | [115] |
| circ_0079593 | oncogene | upregulated | miR-573/ABHD2 | [116] |
| circ_0084043 | oncogene | upregulated | miR-153-3p/Snail miR-429/TRIB2 |
[117] [118] |
| FOXD3-AS1 | oncogene | upregulated | miR-127-3p/FJX1 miR-325/MAP3K2 |
[119] [120] |
| H19 | oncogene | upregulated | miR-106a-5p/E2F3 miR-18b/IGF1 |
[121] [122] |
| HOTAIR | oncogene | upregulated | miR-152-3p/c-MET | [123] |
| KCNQ1OT1 | oncogene | upregulated | miR-153/MET/MYC | [124] |
| LHFPL3-AS1 | oncogene | upregulated | miR-580-3p/STAT3 miR-181a-5p/BCL2 |
[125] [126] |
| LINC00520 | oncogene | upregulated | miR-125b-5p/EIF5A2 | [127] |
| LINC00459 | tumor suppressor | downregulated | miR-218/DKK3 | [128] |
| LINC00518 | oncogene | upregulated | miR-33a-3p/HIF-1α miR-204-5p/AP1S2 |
[129] [130] |
| LINC00961 | tumor suppressor | downregulated | miR-367/PTEN | [131] |
| LINC01158 | oncogene | upregulated | miR-650/MGMT | [132] |
| MALAT1 | oncogene | upregulated | miR-34a/c-Myc, MET miR-183/ITGB1 miR-22/MMP14, Snail |
[133] [134] [135] |
| MEG3 | tumor suppressor | downregulated | miR-499-5p/CYLD miR-21/E-cadherin |
[136] [137] |
| MHENCR | oncogene | upregulated | miR-425/IGF1 miR-489/SPIN1 |
[138] |
| MIR155HG | oncogene | upregulated | miR-485-3p/PSIP1 | [139] |
| MIR205HG | oncogene | upregulated | miR-299-3p/VEGFA | [140] |
| NEAT1 | oncogene | upregulated | miR-23a-3p/KLF3 miR-200b-3p/SMAD2 miR-495-3p/E2F3 |
[141] [142] [143] |
| NORAD | oncogene | upregulated | miR-205/EGLN2 | [144] |
| TUG1 | oncogene | upregulated | miR-129-5p/AEG1 miR-29c-3p/RGS1 |
[145] [146] |
| UCA1 | oncogene | upregulated | miR-28/HOXB3 miR-507/FOXM1 |
[147] [148] |
| XIST | oncogene | upregulated | miR-23a-3p/GINS2 39-5p/ROCK1 |
[149] [150] |
| ZEB1-AS1 | oncogene | upregulated | miR-1224-5p/N/A | [151] |
a compared to healthy tissues and normal cells; N/A, not available.