Figure 1.

PDAC patients can be subclassified based on histopathological and molecular features. (A) Representative H&E sections of a normal human pancreas and a primary PDAC tumor (low grade and high grade). Scale: 200 μm. (B) Schematic overview of the PDAC molecular subtypes described to date [14,15,16,19,20]. Subtypes with similar expression signatures are grouped by color. Low grade PDAC tumors are enriched for a ‘classical’ signature, whereas high grade tumors are enriched for a ‘basal-like’ signature.