Table 1.
Overview of the MET amplified cases assessed by FISH and NGS. Table showing cases #1–43 harboring an amplification of the MET gene determined by FISH or NGS. Cases are arranged according to their FISH classification, descending from high-level amplified cases to low-level amplified cases and descending from cases with the highest MET GCN to the lowest. The columns show the various FISH parameters (MET/CEN7 ratio, MET GCN, CEN7 GCN, MET status and polysomy) as well as the NGS status. Cases which were classified as amplified by the NGS approach are highlighted in green.
| FISH | NGS | |||||
|---|---|---|---|---|---|---|
| Case-ID | MET/CEN7 Ratio | MET GCN | CEN7 GCN | MET Status | Polysomy | NGS Status |
| #1 | >5.00 | >10.00 | 2.00 | High-level amplification | No | Normal |
| #2 | >2.50 | >10.0 | 3.00 | High-level amplification | No | Amplified |
| #3 | 3.30 | >10.0 | 3.00 | High-level amplification | No | Amplified |
| #4 | >2.50 | >10.0 | 4.00 | High-level amplification | Yes | Amplified |
| #5 | >2.50 | >10.0 | 4.00 | High-level amplification | Yes | Amplified |
| #6 | >4.00 | >8.00 | 2.00 | High-level amplification | No | Amplified |
| #7 | 1.10 | 7.60 | 7.20 | High-level amplification | Yes | Normal |
| #8 | 1.40 | 7.00 | 5.00 | High-level amplification | Yes | Normal |
| #9 | 2.00 | 6.00 | 3.00 | High-level amplification | No | Normal |
| #10 | 1.32 | 6.00 | 5.00 | High-level amplification | Yes | Normal |
| #11 | 1.50 | 6.00 | 4.00 | High-level amplification | Yes | Normal |
| #12 | 1.30 | 6.00 | 4.50 | High-level amplification | Yes | Normal |
| #13 | 2.50 | 5.00 | 2.00 | High-level amplification | No | Normal |
| #14 | 3.00 | 4.50 | 1.50 | High-level amplification | No | Normal |
| #15 | 2.70 | 4.40 | 1.60 | High-level amplification | No | Amplified |
| #16 | 2.00 | 4.00 | 2.00 | High-level amplification | No | Normal |
| #17 | 1.38 | 5.50 | 4.00 | Intermediate-level amplification | Yes | Normal |
| #18 | 1.70 | 5.00 | 3.00 | Intermediate-level amplification | No | Normal |
| #19 | 1.70 | 5.00 | 3.00 | Intermediate-level amplification | No | Normal |
| #20 | 1.25 | 5.00 | 4.00 | Intermediate-level amplification | Yes | Normal |
| #21 | 1.00 | 5.00 | 5.00 | Intermediate-level amplification | Yes | Normal |
| #22 | 1.25 | 5.00 | 4.00 | Intermediate-level amplification | Yes | Normal |
| #23 | 1.00 | 5.00 | 5.00 | Intermediate-level amplification | Yes | Normal |
| #24 | 1.25 | 5.00 | 4.00 | Intermediate-level amplification | Yes | Normal |
| #25 | 1.00 | 5.00 | 5.00 | Intermediate-level amplification | Yes | Normal |
| #26 | 1.00 | 5.00 | 5.00 | Intermediate-level amplification | Yes | Normal |
| #27 | 1.00 | 5.00 | 5.00 | Intermediate-level amplification | Yes | Normal |
| #28 | 1.25 | 5.00 | 4.00 | Intermediate-level amplification | Yes | Normal |
| #29 | 0.83 | 5.00 | 6.00 | Intermediate-level amplification | Yes | Normal |
| #30 | 1.26 | 5.00 | 4.00 | Intermediate-level amplification | Yes | Amplified |
| #31 | 1.50 | 4.90 | 3.20 | Low-level amplification | No | Amplified |
| #32 | 1.50 | 4.50 | 3.00 | Low-level amplification | No | Normal |
| #33 | 1.50 | 4.50 | 3.00 | Low-level amplification | No | Normal |
| #34 | 1.50 | 4.50 | 3.00 | Low-level amplification | No | Normal |
| #35 | 1.10 | 4.50 | 5.00 | Low-level amplification | Yes | Normal |
| #36 | 1.13 | 4.50 | 4.00 | Low-level amplification | Yes | Normal |
| #37 | 1.13 | 4.50 | 4.00 | Low-level amplification | Yes | Normal |
| #38 | 1.33 | 4.00 | 3.00 | Low-level amplification | No | Normal |
| #39 | 1.30 | 4.00 | 3.00 | Low-level amplification | No | Normal |
| #40 | 1.14 | 4.00 | 3.50 | Low-level amplification | No | Normal |
| #41 | 1.00 | 4.00 | 4.00 | Low-level amplification | Yes | Normal |
| #42 | 1.00 | 4.00 | 4.00 | Low-level amplification | Yes | Normal |
| #43 | 1.00 | 3.50 | 3.50 | Normal | No | Amplified |