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miR-21 deficiency promotes hepatocarcinogenesis in two distinct HCC animal models through pleiotropic mechanisms. These mechanisms involve subtle alterations of pro-oncogenic (MAPK, HiPPO pathways) and pro-inflammatory signaling pathways (STAT3 pathways), increased cell proliferation and cell cycle progression, increased expression of oncogenes (e.g., Cdc25a), and deregulated immune cells’ infiltration.
