Table 2.
sEV biomarkers for diagnosis and prognosis of PDAC.
| Source | sEV Cargo | Diagnostic/Prognostic Function | Reference |
|---|---|---|---|
| Plasma Serum |
miR-16 miR-196a CA19-9 |
(Early) diagnosis | [206] |
| Serum | miR-20a miR-21 miR-24 miR-25 miR-99a miR-185 miR-191 |
Diagnosis and prognosis | [207] |
| Serum | miR-1290 | (Early) diagnosis | [208] |
| Serum | miR-17-5p | Diagnosis | [198] |
| Serum | miR-21 | Diagnosis | [198] |
| Portal vein blood | Recurrence and prognosis | [199] | |
| Pancreatic juice | Diagnosis | [200] | |
| Plasma | miR-10b | Diagnosis | [209] |
| Plasma | High miR-10b miR-21 miR-30c miR-181a Low miR-let7a |
Diagnosis | [197] |
| Plasma | miR-196a | Diagnosis | [210] |
| Plasma | miR-122-5p miR-125b-5p miR-192-5p miR-193b-3p miR-221-3p miR-27b-3p |
Diagnosis and prognosis | [211] |
| Portal vein blood | miR-451a | Recurrence and prognosis | [199] |
| Pancreatic juice | miR-155 | Diagnosis | [200] |
| Serum | mir-1226 | Diagnosis and prognosis | [212] |
| Serum | miR-1246 miR-4644 miR-3976 miR-4306 CD44v6 Tspan8 EpCAM MET CD104 |
Diagnosis | [213] |
| Plasma | MIF | Prognosis | [153] |
| Serum | GPC1 | Diagnosis and prognosis | [191] |
| Plasma | EGFR EpCAM MUC1 GPC1 WNT2 |
Diagnosis | [194] |
| Plasma | EphA2 | Diagnosis | [110] |
| Plasma | EGFR CA19-9 |
Proposed to have diagnostic potential | [214] |
| Serum | CKAP4 | Diagnosis and monitoring | [215] |
| Serum | c-MET | Prognosis | [202] |
| Serum | PD-L1 | Prognosis | [202] |
| Plasma | CLDN4 EpCAM CD151 LGALS3BP HIST2H2BE HIST2H2BF |
Surface marker for enrichment of PDAC-sEVs |
[205] |
| Plasma | EpCAM | Prognosis | [203] |
| Circulating sEVs | CD44v6 | Prognosis | [216] |
| Circulating sEVs | C1QBP | Prognosis | [216] |
| Serum | ANXA6 | Potential biomarker | [187] |
| Plasma | lnc-Sox2ot | Prognosis | [186] |