Table 1.

Summary of key metabolic genes regulated by nuclear hormone receptor activity in HR+ breast cancer.

Gene	Mechanism of Regulation
Glucose metabolism
GLUT 1,3 and 4	ER and PR regulated
G6PD	Regulated by estrogen
LDHA	Regulated by estrogen
PKM2	Regulated by estrogen
PFKP	Partially regulated by ER through SNAIL
Amino acid metabolism
GLS1	Partially regulated by ER through MYC
GLS2	Partially regulated by ER through GATA3
ASCT2	Partially regulated by ER through MYC
SHMT2	Regulated by ER and through MYC and HIF1α
ABAT	Partially regulated by ER
CAD	Regulated by ER
SNAT2	Partially regulated by ER through HIF1α
SLC7A5	Regulated by ER through LLGL2
Fatty acid metabolism
ABCA1 and ABCG1	Regulated by estrogen, ER and LXR
SCD1	Regulated by estrogen
OCTN2	Regulated by ER
FASN	Regulated by ER, PPARα and PPARγ
ACOX3	Regulated by PPARγ
CPT1A	Regulated by ER/AR/ERRα