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. 2021 Sep 28;13(19):4855. doi: 10.3390/cancers13194855

Figure 5.

Figure 5

HSP27 expression and phosphorylation is upregulated in vivo in tumor xenografts and in ovarian cancer patients. (A) Representative immunofluorescence images of total and p-HSP27 (S78 and 82) in xenograft tumors generated from A2780/vehicle-injected mice and A2780/COL11A1-injected mice. Green: HSP27 (total and phospho); blue: DAPI. Scale bars: 330 µm (10×) and 165 µm (20×). (B) Representative images of IHC staining of p-HSP27 (S78) and COL11A1 in A2780CIS-scrm and A2780-shCOL11A1 tumors. Scale bar: 100 µm. (C) Overall survival in patients expressing high levels of HSP27 mRNA compared to the low-expressing group (left). Overall survival in patients expressing high mean expression of COL11A1 and HSP27 mRNAs compared to the low-expressing group (right).