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. 2021 Sep 23;22(19):10220. doi: 10.3390/ijms221910220

Figure 2.

Figure 2

Validation of effective compounds. (A) Treatment of WT SFs with several concentrations of the compounds to assess the anti-inflammatory potential of the compounds on exogenous induction of TNF. (B) Treatment of hTNFtg SFs, which overexpress hTNF, with several concentrations of the compounds to assess the anti-inflammatory potential of the compounds. (C) Table with IC50s values of (A,B). (D) In vitro TNF-TNFR1 sandwich ELISA to assess the compounds’ potential to inhibit the interaction of TNF with its main receptor TNFR1. All error bars indicate SEM values.