Table 1.
Correlation between clinicopathological patient characteristics and the expression of the insulin receptor (IR) in cancer vessels and cells in PDAC tissues.
| Total | IR Vascular Expression | Cytoplasmic IR Expression | Membranous IR Expression | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low HScore < 135 |
High HScore ≥ 135 |
Low Hscore < 101 |
High HScore ≥ 101 |
Low HScore < 120 |
High HScore ≥ 120 |
||||||||||
| n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | ||
| Gender | n p-Value (a) | 160 | 160 | 1.000 | 160 | 0.527 | 160 | 0.057 | |||||||
| Male | 80 | (50.0) | 39 | (48.8) | 41 | (51.2) | 37 | (46.3) | 43 | (53.8) | 31 | (38.8) | 49 | (61.3) | |
| Female | 80 | (50.0) | 38 | (47.5) | 42 | (52.5) | 42 | (52.5) | 38 | (47.5) | 44 | (55.0) | 36 | (45.0) | |
| Age Group | n p-Value (a) | 160 | 160 | 1.000 | 160 | 0.206 | 160 | 0.342 | |||||||
| <68.3 years | 80 | (50.0) | 39 | (48.8) | 41 | (51.2) | 35 | (43.8) | 45 | (56.3) | 41 | (51.2) | 39 | (48.8) | |
| ≥68.3 years | 80 | (50.0) | 38 | (47.5) | 42 | (52.5) | 44 | (55.0) | 36 | (45.0) | 34 | (42.5) | 46 | (57.5) | |
| T-Category | n p-Value (b) | 147 | 147 | 0.729 | 147 | 0.315 | 147 | 0.278 | |||||||
| T1 | 4 | (2.7) | 2 | (50.0) | 2 | (50.0) | 2 | (50.0) | 2 | (50.0) | 1 | (25.0) | 3 | (75.0) | |
| T2 | 9 | (6.1) | 5 | (55.6) | 4 | (44.4) | 6 | (66.7) | 3 | (33.3) | 4 | (44.4) | 5 | (55.6) | |
| T3 | 130 | (88.4) | 61 | (46.9) | 69 | (53.1) | 69 | (53.1) | 61 | (46.9) | 63 | (48.5) | 67 | (51.5) | |
| T4a/b | 4 | (2.7) | 2 | (50.0) | 2 | (50.0) | 1 | (25.0) | 3 | (75.0) | 3 | (75.0) | 1 | (25.0) | |
| lymph node ratio | n p-Value (a) | 147 | 147 | 0.048 * | 147 | 0.869 | 147 | 0.742 | |||||||
| low (<0.133) | 73 | (49.7) | 41 | (56.2) | 32 | (43.8) | 38 | (52.1) | 35 | (47.9) | 34 | (46.6) | 39 | (53.4) | |
| high (≥0.133) | 74 | (50.3) | 29 | (39.2) | 45 | (60.8) | 40 | (54.1) | 34 | (45.9) | 37 | (50.0) | 37 | (50.0) | |
| N-Category | n p-Value (a) | 147 | 147 | 0.674 | 147 | 0.527 | 147 | 1.000 | |||||||
| N0 | 27 | (18.4) | 14 | (51.9) | 13 | (48.1) | 16 | (59.3) | 11 | (40.7) | 13 | (48.1) | 14 | (51.9) | |
| n+ (N1, N2) | 120 | (81.6) | 56 | (46.7) | 64 | (53.3) | 62 | (51.7) | 58 | (48.3) | 58 | (48.3) | 62 | (51.7) | |
| M-Category | n p-Value (a) | 135 | 135 | 1.000 | 135 | 0.026 * | 135 | 0.289 | |||||||
| M0 | 120 | (88.9) | 53 | (44.1) | 67 | (55.8) | 63 | (52.5) | 57 | (47.5) | 54 | (45.0) | 66 | (55.0) | |
| M1 | 15 | (11.1) | 7 | (46.7) | 8 | (53.3) | 3 | (20.0) | 12 | (80.0) | 9 | (60.0) | 6 | (40.0) | |
| UICC Stage | n p-Value (b) | 129 | 129 | 0.971 | 129 | 0.032 * | 129 | 0.434 | |||||||
| IA | 3 | (2.3) | 2 | (66.7) | 1 | (33.3) | 2 | (66.7) | 1 | (33.3) | 1 | (33.3) | 2 | (66.7) | |
| IB | 2 | (1.6) | 1 | (50.0) | 1 | (50.0) | 1 | (50.0) | 1 | (50.0) | 2 | (100.0) | 0 | (0.0) | |
| IIA | 14 | (10.9) | 6 | (42.9) | 8 | (57.1) | 8 | (57.1) | 6 | (42.9) | 5 | (35.7) | 9 | (64.3) | |
| IIB | 92 | (71.3) | 39 | (42.4) | 53 | (57.6) | 51 | (55.4) | 41 | (44.6) | 43 | (46.7) | 49 | (53.3) | |
| III | 3 | (2.3) | 2 | (66.7) | 1 | (33.3) | 1 | (33.3) | 2 | (66.7) | 1 | (33.3) | 2 | (66.7) | |
| IV | 15 | (11.6) | 7 | (46.7) | 8 | (53.3) | 3 | (20.0) | 12 | (80.0) | 9 | (60.0) | 6 | (40.0) | |
| L-Category | n p-Value (a) | 145 | 145 | 0.619 | 145 | 0.003 * | 145 | 0.620 | |||||||
| L0 | 73 | (50.3) | 37 | (50.7) | 36 | (49.3) | 48 | (65.8) | 25 | (34.2) | 34 | (46.6) | 39 | (53.4) | |
| L1 | 72 | (49.7) | 33 | (45.8) | 39 | (54.2) | 29 | (40.3) | 43 | (59.7) | 37 | (51.4) | 35 | (48.6) | |
| V-Category | n p-Value (a) | 144 | 144 | 0.696 | 144 | 1.000 | 144 | 0.697 | |||||||
| V0 | 110 | (76.4) | 54 | (49.1) | 56 | (50.9) | 59 | (53.6) | 51 | (46.4) | 53 | (48.2) | 57 | (51.8) | |
| V1 | 34 | (23.6) | 15 | (44.1) | 19 | (55.9) | 18 | (52.9) | 16 | (47.1) | 18 | (52.9) | 16 | (47.1) | |
| Pn-Category | n p-Value (a) | 124 | 124 | 1.000 | 124 | 0.544 | 124 | 1.000 | |||||||
| Pn0 | 12 | (9.7) | 6 | (50.0) | 6 | (50.0) | 8 | (66.7) | 4 | (33.3) | 6 | (50.0) | 6 | (50.0) | |
| Pn1 | 112 | (90.3) | 54 | (48.2) | 58 | (51.8) | 59 | (52.7) | 53 | (47.3) | 52 | (46.4) | 60 | (53.6) | |
| Grading | n p-Value (a) | 153 | 154 | 0.054 | 154 | 0.927 | 154 | 0.075 | |||||||
| G1 | 8 | (5.2) | 7 | (87.5) | 1 | (12.5) | 4 | (50.0) | 4 | (50.0) | 4 | (50.0) | 4 | (50.0) | |
| G2 | 78 | (51.0) | 34 | (43.6) | 44 | (56.4) | 40 | (51.3) | 38 | (48.7) | 30 | (38.5) | 48 | (61.5) | |
| G3 | 67 | (43.8) | 30 | (44.8) | 37 | (55.2) | 32 | (47.8) | 35 | (52.2) | 38 | (56.7) | 29 | (43.3) | |
| R-Status | n p-Value (a) | 141 | 141 | 0.072 | 141 | 0.761 | 141 | 0.320 | |||||||
| R0 | 108 | (76.6) | 57 | (52.8) | 51 | (47.2) | 55 | (50.9) | 53 | (49.1) | 55 | (50.9) | 53 | (49.1) | |
| R1 | 32 | (22.7) | 11 | (34.4) | 21 | (65.6) | 18 | (56.3) | 14 | (43.8) | 13 | (40.6) | 19 | (59.4) | |
| R2 | 1 | (0.7) | 0 | (0.0) | 1 | (100.0) | 1 | (100.0) | 0 | (0.0) | 0 | (0.0) | 1 | (100.0) | |
| Diabetes status | n p-Wert (a) | 101 | 101 | 0.874 | 101 | 0.936 | 101 | 0.326 | |||||||
| no diabetes | 73 | (72.3) | 33 | (45.2) | 40 | (54.8) | 38 | (52.1) | 35 | (47.9) | 33 | (45.2) | 40 | (54.8) | |
| type 2 diabetes | 23 | (22.8) | 9 | (39.1) | 14 | (30.9) | 13 | (56.5) | 10 | (43.5) | 7 | (30.4) | 16 | (69.6) | |
| postoperative diabetes | 5 | (5.0) | 2 | (40.0) | 3 | (60.0) | 3 | (60.0) | 2 | (40.0) | 3 | (60.0) | 2 | (40.0) | |
| Overall Survival [Months] | p-Value (c) | 155 | 0.965 | 155 | 0.494 | 155 | 0.378 | ||||||||
| Total/Events/Censored | 155/107/48 | 75/51/24 | 80/56/24 | 76/50/26 | 79 /57/22 | 72/52/20 | 83/55/28 | ||||||||
| Median Survival | 14.9 ± 1.9 | 15.0 ± 1.3 | 13.7 ± 3.9 | 12.9 ± 1.8 | 19.1 ± 4.1 | 13.5 ± 2.3 | 14.9 ± 4.1 | ||||||||
| 95% C.I. | 11.1–18.6 | 12.4–17.5 | 6.0–21.4 | 9.4–16.4 | 11.1–27.2 | 9.0–17.9 | 6.8–23.0 | ||||||||
| Tumor Specific Survival [Months] | p-Value (c) | 153 | 0.804 | 153 | 0.512 | 153 | 0.478 | ||||||||
| Total/Events/Censored | 153/100/53 | 73/48/25 | 80/52/28 | 75/47/28 | 78/53/25 | 70/47/23 | 83/53/30 | ||||||||
| Median Survival | 15.7 ± 1.9 | 15.7 ± 1.7 | 15.0 ± 4.3 | 13.7 ± 2.0 | 19.2 ± 5.0 | 15.1 ± 1.7 | 18.7 ± 4.8 | ||||||||
| 95% C.I. | 11.9–19.4 | 12.3–19.1 | 6.6–23.4 | 9.8–17.5 | 9.4–28.9 | 11.7–18.3 | 9.3–28.0 | ||||||||
(a) Fisher’s exact test, (b) Kendall’s tau test, (c) Log-rank test. * p values having lost significance according to the Siemes (Benjamini-Hochberg) procedure for multiple testing.