. 2021 Oct 5;13(19):4988. doi: 10.3390/cancers13194988

Table 4.

Comparison of insulin receptor (IR) and IGF1 receptor expression between pancreatic cancer samples and corresponding intratumoral PanIN lesions.

	PanIN Low Grade Cytoplasmic IR Expression			PanIN High Grade Cytoplasmic IR Expression
	Low (HScore < 101)	High (HScore ≥ 101)	p -Value (a)	Low (HScore < 101)	High (HScore ≥ 101)	p -Value (a)
Tumoral cytoplasmic IR expression	n (%)	n (%)		n (%)	n (%)
low (HScore < 101)	7 (43.8)	9 (56.3)	0.716	1 (20.0)	4 (80.0)	0.301
high (HScore ≥ 101)	5 (33.3)	10 (66.7)	0.716	5 (55.6)	4 (44.4)	0.301
	PanIN Low Grade Membranous IR Expression			PanIN High Grade Membranous IR Expression
	Low (HScore < 120)	High (HScore ≥ 120)	p -Value (a)	Low (HScore < 120)	High (HScore ≥ 120)	p -Value (a)
Tumoral membranous IR expression	n (%)	n (%)		n (%)	n (%)
low (HScore < 120)	7 (53.8)	6 (46.2)	0.481	3 (100)	0 (0.0)	0.258
high (HScore ≥ 120)	7 (38.9)	11 (61.1)	0.481	6 (54.5)	5 (45.5)	0.258
	PanIN Low Grade Cytoplasmic IGF1R Expression			PanIN High Grade Cytoplasmic IGF1R Expression
	Low (HScore < 10)	High (HScore ≥ 10)	p -Value (a)	Low (HScore < 10)	High (HScore ≥ 10)	p -Value (a)
Tumoral cytoplasmic IGF1R expression	n (%)	n (%)		n (%)	n (%)
low (HScore < 10)	13 (61.9)	8 (38.1)	0.441	6 (85.7)	1 (14.3)	0.103
high (HScore ≥ 10)	4 (40.0)	6 (60.0)	0.441	2 (28.6)	5 (71.4)	0.103
	PanIN Low Grade Membranous IGF1R Expression			PanIN High Grade Membranous IGF1R Expression
	Low (HScore <12)	High (HScore ≥ 12)	p -Value (a)	Low (HScore <12)	High (HScore ≥ 12)	p -Value (a)
Tumoral membranous IGF1R expression	n (%)	n (%)		n (%)	n (%)
low (HScore <12)	15 (75.0)	5 (25.0)	0.423	6 (100)	0 (0.0)	0.031 *
high (HScore ≥ 12)	6 (54.5)	5 (45.5)	0.423	3 (37.5)	5 (62.5)	0.031 *

(a) Fisher’s exact. * p values having lost significance according to the Siemes (Benjamini-Hochberg) procedure for multiple testing.