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Change in serum adiponectin:leptin ratio at 12 and 24 weeks as a function of visceral fat lost, both relative to baseline values. Diamonds denote participants in cohort 1; circles denote participants in cohort 2 (blue = 12-week values; orange = 24-week values). Linear regression yields a slope of 6.6% change in adiponectin:leptin ratio per percent visceral fat loss (p < 0.001).
