Table 1.
Classification of nucleic acid drugs.
| Regulation Type | Name | Structure | Length (nt) | Representative Companies |
|---|---|---|---|---|
| Inhibition | ASO | ssDNA | 13–30 | Ionis, Nippon Shinyaku |
| siRNA | dsRNA | 20–30 | Alnylam, Dicerna, Quark | |
| Splice switching | SSO | ssDNA | 20–30 | Sarepta, Ionis |
| Editing | EON | ssRNA | 20–40 | ProQR |
| Augmentation | saRNA | dsRNA | 20–30 | MiNA |
| Replacement | miRNA mimic | dsRNA | 20–30 | Mirna, miReven |
| mRNA | ssRNA | hundreds to thousands | BioNTech, Moderna |
ssDNA, single strand DNA; dsRNA, double strand RNA, ssRNA, single strand RNA.