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Architecture and main cellular components of the germinal center. The germinal center is mainly divided into two zones; the Dark zone (DZ) where GC B cells undergo somatic hypermutation (SHM) of their immunoglobulin (Ig) genes and the light zone (LZ) where GC B cells interact with antigens presented to them by FDCs as well as T follicular helper cells (Tfh). GC: germinal center, FDCs: follicular dendritic cells.
