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Possible therapeutic targets on Tfh cells for the treatment of RA. Several molecules and receptors expressed on Tfh can be targeted to dampen aberrant immune responses in RA such as anti-ICOS, anti-CTLA4, anti-OX40, anti-CXCR5, Anti-CD40, IL-21 antagonist and IL-4 antagonist. CR2, complement receptor 2; FDC, follicular dendritic cell.
