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Biochemical pathway of DHA biosynthesis. In the endoplasmic reticulum, α-linolenic acid is converted to tetracosahexaenoic acid by the action of elongases and desaturases. Then, in the peroxisome (yellow arrow: electron microscopy of C2C12 myoblasts; provided by Imen Ghzaiel, PhD student), β-oxidation occurs and leads to the synthesis of DHA.
