Table 2.

Evidence for the involvement of functional pathways in FTLD-TDP following the different proteomic studies. The table indicates which studies reported proteins related to the six main pathways. Note that this overview is based on all proteins reported as significantly altered in FTLD-TDP, and does not always correspond to the pathways highlighted by individual studies (as shown in Table 1). The last two columns provide the major overlapping proteins and protein families, and candidate proteins of individual studies that were confirmed dysregulated in FTLD-TDP by additional validation experiments (e.g., immunoblotting, immunohistochemistry). The proteins of both columns combined are also depicted in Figure 1. A complete list of overlapping proteins can be found in Table S1.

Functional Pathway	Umoh et al. [38]	Andrés- Benito et al. [39]	Iridoy et al. [40]	Lachén-Montes et al. [41]	Gozal et al. [42]	Gozal et al. [43]	Seyfried et al. [32]	Laferrière et al. [44]	Herszk-owitz et al. [45]	Overlapping Proteins /Protein Families	Validated Proteins
RNA metabolism	X	X			X		X	X		hnRNPs, CSRP1	PSF
Neuroinflammation	X	X			X	X		X	X	GFAP, MSN, HEPACAM, PRDX6	GFAP, MSN, HEPACAM
Endolysosomal system	X	X	X	X	X		X	X		Annexins, Rabs, ASAH1, CLTC, CTSD, PPT1	TPP1, ASAH1
Cytoskeleton	X	X	X	X	X	X	X	X	X	Septins, CTTN, GFAP, MSN	SEPT3, SEPT7, SEPT11, NDRG2
Mitochondrial functioning	X	X	X		X		X	X		Prohibitins, NDUFs, UQCRs, ATP5A1,	PHB1, PHB2
Synaptic functioning	X	X	X	X	X	X			X	Syntaxins, SNAP25, PRRT2	SNAP25