Apnea duration (s) and time to righting (min) in rats randomized to different treatment groups. (A) Apnea duration did not differ between rats with TBI randomized to either vehicle (TBI-VEH) or NAC+SFN duotherapy (TBI-DUO) (p > 0.05, independent sample t-test). (B) Time to righting was longer in rats with TBI than in sham-operated experimental controls (TBI-VEH vs. Sham-VEH, p < 0.05; TBI-DUO vs. Sham-DUO, p < 0.01). No difference was detected between rats randomized to the TBI-VEH or TBI-DUO groups (p > 0.05, independent sample t-test). Data are presented as whisker-plots with mean and minimum/maximum. Abbreviations: D, day; DUO, duotherapy treated with N-acetylcysteine and sulforaphane; NAC, N-acetylcysteine; SFN, sulforaphane; TBI, traumatic brain injury; VEH, vehicle. Statistical significances: * p < 0.05, between Sham-VEH and TBI-VEH groups (independent sample t-test), ** p < 0.01 between Sham-DUO and TBI-DUO groups (independent sample t-test).