Body weight. Mean body weight of each treatment group at different time-points after sham-operation or traumatic brain injury (TBI) over the 2-week follow-up. The weight of Sham-VEH or Sham-DUO treated animals returned to the pre-operation (day [D] 0) weight by D11. TBI-VEH or TBI-DUO treated animals, although they gained weight, did not reach their D0 weight during the follow-up. Overall, body weight did not differ between treatment groups at any time-point (p > 0.05, Mann–Whitney U-test). Abbreviations: D, day; DUO, duotherapy treated with N-acetylcysteine and sulforaphane; g, gram; TBI, traumatic brain injury; VEH, vehicle; wk, week. Statistical significances: * p < 0.05, compared to D0 within Sham-VEH group; # p < 0.05, compared to D0 within Sham-DUO group; ¤ p < 0.05, compared to D0 within TBI-VEH group; § p < 0.05, compared to D0 within TBI-DUO group (Wilcoxon). Data are presented as mean ± SEM.