Skip to main content
. 2021 Sep 29;22(19):10555. doi: 10.3390/ijms221910555

Figure 6.

Figure 6

Beam walking in rats treated with vehicle or SFN+NAC duotherapy. (A) Both TBI-VEH and TBI-DUO groups were impaired in the beam walking test until day (D) 13 post-TBI. (B) A whisker-plot showing the distribution of scores in each animal throughout the 2-week follow-up. Interestingly, rats in the TBI-VEH group tended to cluster into the poorly-performing group (6 of 10 rats [60%] scoring 0-1) and rats in the TBI-DUO group into well-performing group (6 of 9 rats [67%] scoring 4-6), particularly at the end of the testing period. (C) The TBI-VEH group was impaired in beam crossing throughout the 2-week follow-up. The TBI-DUO group improved after D2, and did not differ from the Sham-DUO group on D13. Abbreviations: D, day; DUO, duotherapy treated with N-acetylcysteine and sulforaphane; NAC, N-acetylcysteine; SFN, sulforaphane; TBI, traumatic brain injury, VEH, vehicle; wk, week. Statistical significances: ** p < 0.01, *** p < 0.001 (Sham-VEH vs. TBI-VEH, independent sample t-test); # p < 0.05, ### p < 0.001 (Sham-DUO vs. TBI-DUO, independent sample t-test); ¤ p < 0.05, ¤¤ p < 0.01, ¤¤¤ p < 0.001 as compared to corresponding baseline (paired sample t-test). Data are presented as mean ± SEM or as whisker-plots with mean and minimum/maximum.