Figure 3.

Superposition of individual chains of Trop2 ectodomain from the asymmetric unit shown in two orientations depicting (a) triangular domain arrangement, and (b) TY-loop protruding from the subunit. Chains are shown in ribbon representation with color-coding corresponding to individual domains (ND in olive, TY in light blue, CD in pink). Disulfide bonds, carbohydrate residues (CH), and sulfate ion (SO₄²⁻) are shown as yellow, grey, and black sticks, respectively. Unmutated potential N-glycosylation sites (N33, N168) and mutated ones (N120Q, N208Q) are shown as grey sticks. For clarity, individual amino acid and carbohydrate residues and the sulfate ion are shown only for chain A. Ridge region within the CD (RCD) is shown in orange, and the TY-loop of chains A and B in dark blue. Labels N and C denote N- and C-termini, respectively.