Table 1.

Biochemical parameters in hHTG rats treated with empagliflozin compared to control.

Parameter	Units	Control	Empagliflozin
Urinary glucose	mmol/L	0.9 ± 0.2	93.7 ± 12.2 ***
Glucose fasted	mmol/L	5.314 ± 0.347	4.407 ± 0.131 *
Glucose postprandial	mmol/L	8.296 ± 0.347	7.969 ± 0.248
Insulin	nmol/L	0.221 ± 0.024	0.142 ± 0.024 *
TAG	mmol/L	4.750 ± 0.294	3.12 ± 0.226 ***
CHOL	mmol/L	1.567 ± 0.014	1.536 ± 0.032
HDL-C	mmol/L	0.760 ± 0.021	0.913 ± 0.037 **
NEFA	mmol/L	0.426 ± 0.027	0.666 ± 0.083 **
Glycerol	mmol/L	0.192 ± 0.013	0.203 ± 0.013
Leptin	pg/mL	4425 ± 220	3508 ± 245 *
MCP-1	pg/mL	149.62 ± 67.25	123.1 ± 15.5

Data are expressed as mean ± SEM; * p ˂ 0.05, ** p ˂ 0.01, *** p ˂ 0.001. TAG: plasma triglycerides; CHOL: plasma cholesterol; HDL-C: HDL cholesterol; NEFA: non-esterified fatty acids; MCP-1: monocyte chemoattractant protein 1. Control group (n = 7) and empagliflozin group (n = 8). Empagliflozin group received standard diet enriched by 0.01% empagliflozin for 6 weeks.