Table 3.
Significantly changed metabolites in plasma.
| Metabolite | NMR Signal Used for Quantitation [ppm] |
(Empag-Control)/ Control [%] |
p-Value |
|---|---|---|---|
| Acetone | 2.24 (s) | 138.5 | 0.002 |
| β-Hydroxybutyrate | 1.20 (d) | 66.7 | 0.043 |
| Leucine | 0.97 (m) | 12.6 | 0.028 |
| Pyruvate | 2.38 (s) | −33.3 | 0.007 |
| Alanine | 1.49 (d) | −14.2 | 0.003 |
| Tyrosine | 6.91 (m) | −20.0 | 0.034 |
| Threonine | 4.25 (dd) | −11.5 | 0.008 |
| Cytidine | 6.07 (d) | −9.6 | 0.021 |
| Tryptophan | 7.29 (m) | −8.1 | 0.058 |
Data are expressed as the percentage change of normalised concentrations in empagliflozin versus control groups. Statistical significance was determined by the unpaired Student t-test. Control group (n = 7) and empagliflozin group (n = 8). Empagliflozin group received a standard diet enriched by 0.01% empagliflozin for 6 weeks. Signal multiplicity is marked as follows: (s)-singlet, (d)-doublet, (dd)-doublet of doublets, (m)-multiplet.