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. 2021 Sep 28;22(19):10496. doi: 10.3390/ijms221910496

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Disulfiram inhibited therapeutic resistance-induced cell mobility. A 20% dose of Disulfiram (DSF) growth inhibitor was selected. 0.1% DMSO was used as solvent control (labelled as 0 μM). The cell mobility was evaluated using a two-dimensional (2D) wound healing assay and a three-dimensional (3D) Transwell assay. (A) Graphs of the wound and histogram showing the inhibitory effects of DSF on 2D cell mobility of 1306MG, radiation-resistant 3.5GR6, and radiation-TMZ-resistant R6T3; N = 3; scale bar = 100 μm; (B) graphs and histogram showing the inhibitory effect of DSF on 2D cell mobility of U87MG, radiation-resistant 2GR4, and radiation-TMZ-resistant R4T3; N = 3; scale bar = 100 μm; (C) graphs showing the migratory cells and histogram indicating the cell mobility of the inhibitory effect of DSF on 3D cell mobility of U87MG, radiation-resistant 2GR4, and radiation-TMZ-resistant R4T3; N = 5; scale bar = 20 μm; mean ± SEM; a refers to a comparison with parental 1306MG or U87MG; b refers to a comparison with the control; a and b, p < 0.05; aa and bb, p < 0.01.