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. 2021 Sep 28;22(19):10472. doi: 10.3390/ijms221910472

Figure 4.

Figure 4

Effect of xyloglucan on cytokine quantification in the BALF of OVA-sensitized mice. OVA-sensitized mice exposed an extensive upregulation of cytokines in the BALF, compared to the sham groups (A–F). However, treatment with XG-based spray proved to be successful in reducing the expression of proinflammatory cytokines IL-12, IL-25, IL-13, IL-33, IL-4 and IL-5 in BALF of mice (A–F). This decrease was quantitatively greater when XG spray was associated with antihistamine, thus becoming comparable to the effects obtained with corticosteroid administration. Data are representative of at least three independent experiments. Values are means ± SEM. One-Way ANOVA test. *** p < 0.001 vs. Sham; °° p < 0.01 vs. AR + vehicle; °°° p < 0.001 vs. AR + vehicle; +++ p 0.001 vs. AR + Corticosteroid.