Figure 6.

Effect of XG on OVA-specific and total serum IgE levels. Increased levels of IgE were found in the serum of AR-mice compared to the sham animals. The XG-based spray was able to markedly reduce serum total and OVA-specific IgE in a way comparable to mast cell stabilizer and antihistamine single treatments (A,B). In addition, co-treatment consisting of XG and antihistamine effectively modulated IgE, OVA-specific and total serum levels, similarly to treatment with corticosteroid (A,B). Data are representative of at least three independent experiments. Values are means ± SEM. One-Way ANOVA test. *** p < 0.001 vs. Sham; °°° p < 0.001 vs. AR + vehicle; +++ p 0.001 vs. AR + Corticosteroid. ns: not significant.