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. 2021 Sep 28;22(19):10472. doi: 10.3390/ijms221910472

Figure 8.

Figure 8

Effect of XG treatment on HDAC1 expression. OVA-challenged nasal mucosa exposed an evident increase of HDAC1 expression (G, histological score N) compared to the sham groups (A–F, histological score N); Single treatments with XG-based spray significantly reduced HDAC1 expression (H,I, histological score N) similarly to antihistamine (K, histological score N) and mast cell stabilizer (J, histological score N) administrations. Co-treatment consisting of XG and antihistamine proved to be efficacious in decrease HDAC1 levels (L, histological score N), analogously to treatment with corticosteroid (M, histological score N). Data are representative of at least three independent experiments. Values are means ± SEM. One-Way ANOVA test. *** p < 0.001 vs. Sham; °° p < 0.01 vs. AR + vehicle; °°° p < 0.001 vs. AR + vehicle; +++ p 0.001 vs. AR + Corticosteroid.