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. 2021 Sep 28;22(19):10472. doi: 10.3390/ijms221910472

Figure 9.

Figure 9

Effect of XG treatment on ZO-1 expression. OVA-sensitized nasal mucosa revealed a marked reduction of ZO-1 expression (G, histological score N) compared to the sham animals (A–F, histological score N); XG-based spray treatment significantly preserved ZO-1 expression (H,I, histological score N) as well antihistamine (K, histological score N) and mast cell stabilizer (J, histological score N) administrations. However, a quantitatively more substantial effect was obtained from the co-administration of XG and antihistamine (L, histological score N) and corticosteroid treatment (M, histological score N). Data are representative of at least three independent experiments. Values are means ± SEM. One-Way ANOVA test. *** p < 0.001 vs. Sham; °°° p < 0.001 vs. AR + vehicle; +++ p 0.001 vs. AR + Corticosteroid.