Figure 1.

Sample patient timelines showing how physiologic and treatment parameters are tracked over time to enable identification of sepsis (rise in Sequential Organ Failure Assessment [SOFA] score with antibiotic escalation) or septic shock (sepsis with lactate greater than 2 mmol/L and cardiovascular SOFA greater than 2). A, Data for a patient who did not have an episode of sepsis. B, Data for a patient who was on rank 4 antibiotics and had a high SOFA score at admission, but did not have an elevated lactate, and, therefore, was considered to have sepsis but not septic shock. C, Data for a patient who did not have sepsis at admission, but developed a 2-point rise in total SOFA, with cardiovascular SOFA greater than 2, along with a new antibiotic prescription and raised lactate, and hence met the criteria for septic shock on day 2.