Figure 5.

The modular representation of the integrated model at the physiological level. The model comprises five modules: “Capillary_Blood_Flow” to describe flow processes in the blood; “Cytosol_Capillary Transport R” and “Cytosol_Capillary Transport W” modules representing transport reactions between capillary blood and the muscle tissue, “Fiber R” and “Fiber W” modules where metabolic, signaling, and gene expression regulation processes are considered. All details for each submodule and zoomed-in subfigures are in the Supplementary Material.