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. 2021 Sep 26;22(19):10353. doi: 10.3390/ijms221910353

Figure 12.

Figure 12

Simulation results for low and moderate intensity (50% (A–E) and 70% (F–K) VO2max, respectively) continuous exercises (30 min for signaling and 60 min for gene expression) with intermediate X factor regulating the expression of the PPARGC1A gene. (A,F) Ratio of CAMKII phosphorylated protein in type I (red) and type II (blue) fibers (corresponds to [53]); (B,C,G,H) Percentage of all α2 phosphorylated proteins (dashed) and of the phosphorylated γ3 heterotrimers (solid) in type I fibers and type II fibers, respectively (corresponds to [65,96]); (D,I) Expression (in fold changes) of NR4A3 (thunderbird solid), NR4A2 (orange solid), PPARGC1A (red solid) in type I fibers and (E,J) in type II fibers, where NR4A3—sapphire solid, NR4A2—azure solid, PPARGC1A—blue solid; (K) Expression (in fold changes) of NR4A3 (green solid), NR4A2 (magenta solid), and PPARGC1A (purple solid) in the muscle tissue during moderate intensity exercise.