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. 2021 Sep 22;22(19):10204. doi: 10.3390/ijms221910204

Figure 4.

Figure 4

SCH772984 downregulates transcripts associated with the immune response and hemostasis in kidney and liver tissues, and positively regulates ECM and retinoic acid pathways in the lungs and liver, respectively, in a CLP-induced mouse model of sepsis. The numbers of differentially expressed genes (adj. p-value < 0.05) across the organs and two time points in the sham vs. CLP groups (A) and upon SCH772984 (10 mg/kg) treatment (B). Red and green arrows indicate up- and downregulated genes, respectively. Venn diagrams show the overlapping numbers of DEGs for organs at a given time point post-CLP for up-and downregulated genes. (C) Significantly altered (adj. p-value < 0.05) recurrent Reactome terms across the organs and time points in the sham vs. CLP and the CLP vs. CLP+ SCH772984 groups. The Reactome pathways with a differential gene ratio higher than 10% and recurrently altered in more than two types of samples are shown. The p-value is shown on the PHRED scale and is reversed for downregulated pathways.