Table 2.

Cytotoxicity and selectivity index (SI) values of the Mannich bases 9–16.

Compound No.	Wi-38		MDA-MB 231		Caco-2
	EC100 (µM) *	EC50 (µM)	IC50 (µM)	SI	IC50 (µM)	SI
9	0.638 ± 0.029	1.324 ± 0.024	1.733 ± 0.068	0.763	2.292 ± 0.084	0.577
10	1.460 ± 0.026	2.250 ± 0.048	1.388 ± 0.082	1.621	1.628 ± 0.006	1.382
11	0.653 ± 0.036	1.755 ± 0.039	2.354 ± 0.022	0.745	2.121 ± 0.009	0.827
12	0.984 ± 0.034	2.745 ± 0.054	1.146 ± 0.093	2.395	3.313 ± 0.110	0.828
13	0.591 ± 0.048	1.145 ± 0.042	0.733 ± 0.056	1.562	0.609 ± 0.016	1.880
14	0.850 ± 0.036	1.721 ± 0.056	2.037 ± 0.044	0.844	1.727 ± 0.028	0.996
15	0.804 ± 0.016	1.089 ± 0.007	0.306 ± 0.010	3.558	0.264 ± 0.001	4.125
16	0.463 ± 0.034	0.779 ± 0.033	0.404 ± 0.015	1.928	0.390 ± 0.001	1.997
5-Fluorouracil	1.067 ± 0.002	2.915 ± 0.052	21.019 ± 0.032	-	0.437 ± 0.016	-

* All values are expressed are mean ± SEM.